Here is a setup from

Dymo Label # 30334, 2 1/4" x 1 1/4"

For different labels, you will need to adjust the "label width" and "label height" fields, and may have to play with checking and unchecking the "portrait" box.

 

Here are the settings for the DYMO LabelWriter 450 from Brad, N8SNM

DYMO LabelWriter 450 settings